Why liposomes ?

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Why liposomes

Almost two years have passed since we started writing articles dealing with Lyme disease issues for you. Together with Gosia, we search, analyze, translate and interpret everything that can have educational value. We also share with you our experience, which each patient acquires over the years of struggle not only with the disease, but also with an unchangeable system.

What would the world look like if there were no antibiotics discovered 90 years ago? It is hard to imagine today. The World Health Organization reports that hundreds of thousands of patients die every year as a result of a direct infection with antibiotic-resistant bacteria. New resistance mechanisms appear and spread throughout the world, threatening our ability to cure common infectious diseases, resulting in death or disability. The world is moving towards the post-antibiotic era, in which ordinary infections or minor injuries that could be treated for decades can start killing again.

Will liposomal technologies stop the enemy? The team, led by Swiss cell biologists, has constructed liposomes that act as baits, pulling away toxic odors from bacteria, isolating and neutralizing them. These toxins not only cause us to be sick, they are also the defense line of invasive bacteria. When the toxins are neutralized by the liposomes, the weak and defenseless bacteria are easily eliminated by the host’s immune system. Liposomal delivery systems are used in anticancer drugs and antibiotics. Almost with pharmaceutic precision, they target the host’s intracellular microorganisms by destroying the biofilm community. The most attractive feature of liposome-based drugs is their strengthening of the therapeutic index of new or existing drugs while minimizing their adverse effects.

Liposomes are now widely used as universal carriers of all substances in the cosmetics and pharmaceutical industries. Manipulation of the different physicochemical properties of the liposomes enables the design of individual carriers with the desired pharmacokinetic and pharmacodynamic properties. Most research on antibiotics and liposomal herbs focuses on improving pharmacokinetic properties and reducing toxicity, while others concern increasing antimicrobial activity. In an era of rapidly growing bacterial resistance and serious problems in the treatment of bacterial infections, the use of liposomal carriers is useful, but the high cost of preparation and treatment should also be taken into account.

Biofilm is closely related to chronic infections and is difficult to root out. The development of effective therapeutic strategies to control infection with biofilm continues to be a major challenge for researchers. Striving for biofilm architecture, Jan Oruba has developed herbal liposomal formulas that, together with synergistic antibiotic therapy, effectively track and damage biofilms. Liposomes with a positive charge and small size are insidiously and deliberately sucked in by the biofilm microcanals, destroying the community from the inside.

Liposomal formulations of preparations, is a faster and better absorption of active substances. The potential harmfulness of such formulas for healthy cells is at a minimum. Small amounts of various substances can be provided by small lipid molecules. The new formula thanks to nano technology, is better absorbable and has increased compatibility with the components of cell membranes. Nanoliposomes are small vesicles that are made of lipid (fat) molecules and their derivatives. Extracts and essential oils are enclosed inside. Such a “capsule” has a composition resembling our cell membrane, therefore it is easier to penetrate inside the cells. Thanks to their special composition, their “films” are designed to release internally contained active ingredients in cells that are their target.

Numerous studies show that chemical compounds of natural origin can have a powerful effect, protecting against many diseases – including Lyme disease. Interest in the use of liposomes in the case of dietary supplements and medicines derived from plants is associated with the results of scientific studies that reveal poor absorption or bioavailability. Particles of various herbs are too large, and they have too complicated structure, so that they can easily penetrate the intestinal mucosa, and from there to the blood. The use of liposomes allows this barrier to be bypassed due to their biocompatibility with the intestinal wall. This means that liposomal-building lipids resemble the intestinal cell membrane, which makes it easier for them to penetrate. Liposomes protect active ingredients against degradation in the liver, as well as during the transport of substances through the circulatory system, thanks to which the drug circulates longer in the body, which also increases the chances of its reaching the place of action.

For two years I have not experimented with drugs, maintaining my level of health at a satisfactory level. Gosia ended her treatment four years ago, letting the disease keep on making itself known by generating various ailments. Will Oruba Protocol improve our quality of life soon we will see. I’m already drinking, Gosia is waiting and going from liposomal to the form from September.

https://www.tandfonline.com/doi/abs/10.1517/17425247.2013.822860?https://www.ncbi.nlm.nih.gov/pubmed/29651836

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