Great imitator III

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Brucellosis

The first “big imitator” was called syphilis,

which caused changes very similar to the symptoms of other infectious diseases. At the end of the last century, people have started calling Lyme disease by that name, because its symptoms are diverse and can be confused with the symptoms of many other diseases. In recent years another “great imitator” appeared – brucellosis.

As in the case of Lyme disease, brucellosis manifests symptoms similar to other diseases transmitted by ticks. Brucellosis is a very small rod-shaped bacterium that penetrates cells at an early stage of infection, causing repetitive low fevers, sweating and migraine pain. Untreated in later stages, it concentrates in the bones, joints, organs of the lymphatic system and the nervous system. Chronic infection causes sweats that smell of wet hay. Untreated at an early stage, as a consequence, triggers a cascade of neurological disorders, called neurobrucellosis. There may be hepatitis, swelling of the liver and spleen, endocarditis, arthritis, anemia, uveitis, optic neuritis, endocarditis, meningitis, miscarriage, chronic fatigue and depression.

Unfortunately, the erroneous diagnosis of brucellosis is very common.

Neurobrucellosis (NB) is often undiagnosed, which is partly due to the unconsciousness of the disease among the treating physicians. Erroneous diagnosis of patients with brucellosis is greater than 50%. It is believed that this is due to the similarity of the symptoms of brucellosis with other diseases. Blood tests often give false negative results. Clinically, it is not accepted as a chronic disease. In NB, the nervous system can be affected in both the acute and chronic stages of the disease. Clinical presentation includes meningitis, meningitis, vascular involvement, peripheral neuropathy, radiculopathy and demyelinating disease.

Brucellosis can lead to hematological disorders, including cytopenias, confusing the diagnosis of hematopoietic neoplastic diseases. Cytopenia is very characteristic of lupus and is manifested by a deficiency of red blood cells or white blood cells. We talk about it when the production of blood cells is reduced. A known example is the reduced number of red blood cells (erythrocytes), is also called anemia. Research from this year suggests that patients with cytopenias should be screened for hidden brucellosis.

Neurobrucellosis may be perceived as meningitis and encephalopathy and may cause cranial nerve pathologies (particularly VIII), vascular syndromes, myopathies, diseases of the spine (inflammation of the vertebrae) and mental disorders. It mimics the stroke, causes inflammation of small and large blood vessels like bartonellosis.

During neurobucciosis, there may be a significant increase in ferritin in the blood, which usually suggests hemophagocytic lymphohistiocytosis (HLH). It is a hyperpapalasia state in which (in adults usually under the influence of Epstein-Barr virus infection) first cytotoxic lymphocytes paralyze, followed by self-accelerating stimulation of first type T lymphocytes that overproduce proinflammatory cytokines, which in turn activate macrophages (histiocytes ). Cytokines in large quantities cause metabolic disorders and damage to many organs.

the tick sits on a green leaf in the forest

Recently, many species of brucellosis resistant to antibiotic treatment have appeared, which are already present in various regions of the world.

It has also recently been proven that brucellosis is transmitted by ticks. As a co-infection, it may initially not give any classic symptoms, hiding in the cells of the human body. The bacterium has the ability to produce a biofilm that protects it against the immune system and drugs. It is presumed that biofilm protects bacteria 5000 times more effectively, which explains its drug resistance.

drop of medical plantTo successfully fight bacteria, natural protocols based on liposomal herbs and essential oils were created. The liposomal protocol includes:
* Oliveriadecumbens (Umbliferae), a medicinal plant used in traditional medicine in India and Iran.
* Salvia sclarea contains volatile oils with diastolic and sedative effects.
* Cultivated saffron (Crocus sativus)
It is required to process these herbs into a liposomal mixture to increase their ability to penetrate into the cells of macrophages, biofilms, joints and the nervous system.

However, among the essential oils dominating in the fight against brucellosis, we can mention
* Origanumsyriacum
* Thymus syaricus
* Cinnamomumverum

COMPLICATIONS

* Infection of the inner lining of the heart (endocarditis). This is one of the most serious complications associated with brucellosis. Untreated endocarditis can damage or destroy heart valves which also may lead to the cause of brucellosis-related deaths.
*Arthritis. Joint infection is characterized by pain, stiffness and swelling of the joints, especially of the knees, hips, ankles, wrists and spine. Arthritis of the spine – inflammation of the joints between the vertebrae or between the spine and the pelvis – can be particularly difficult to treat and can cause permanent damage.
* Inflammation and testicular infection. Swelling and pain caused by brucellosis can be severe.
* Inflammation and infection of the spleen and liver.
* Infections of the central nervous system. These include potentially life threatening diseases such as meningitis, inflammation of the membranes surrounding the brain and spinal cord, and inflammation of the brain itself.

Sources:

https://www.ncbi.nlm.nih.gov/pubmed/29241765
https://scialert.net/abstract/?doi=ijp.2010.117.122
https://www.mayoclinic.org/diseases-conditions/brucellosis/symptoms-causes/syc-20351738
https://www.ncbi.nlm.nih.gov/pubmed/19299290
https://www.ncbi.nlm.nih.gov/pubmed/22495564
https://www.ncbi.nlm.nih.gov/pubmed/15370648
https://www.ncbi.nlm.nih.gov/pubmed/20497223

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