Dominant co-infection–Rickettsia

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Rickettsia co-infection Lyme

Rickettsia has recently been considered the main player in Lyme disease. Rickettsia is divided into three groups (spotted fever, typhus and typhoid) and all three are pathogenic to humans. Ricketts are more widespread than previously thought. They are obligatory intracellular parasites and attack the endothelial cells of blood vessels in target organs, damaging them and causing increased vascular permeability with the consequences of edema, hypotension and hypoalbuminemia.

This means that infection with this bacterium in Lyme will be characterized by edema in various parts of the body. Diseases caused by this bacterium are very difficult to diagnose clinically, even for experts. Non-specific symptoms and presentation vary between patients. Sometimes they may be headaches or general malaise, fever, and in some cases, nausea and vomiting. The bacterium is largely underestimated by the medical community and is still poorly understood. There are many strains and species of Rickettsia that are very harmful and for which tests do not exist. Recent research indicates that there are probably more than 1,000 strains of this bacterium.

It was thought that rickettsia is definitely simpler than the dynamically changing borrelia and they do not have so many stages of growth or so many forms. That’s why it seemed easier to heal. But it is not necessarily a real thesis. Rickettsia can survive months of antibiotic treatment. A characteristic symptom is skin lesions, usually on the hands and soles. Rickettsia also causes stagnation of the circulatory system and dense blood, causing inflammation of the blood vessels and also causing the skin to be spotted and mottled. The patient has the impression that his system is overloaded and detoxification is not working properly. Swelling is common. Patients complain of swollen ankles or swollen face and / or eyes after waking up.

Cognitive problems are confused with babesia infection. The patient has the impression that he has suffered from Alzheimer’s disease. He’s lost in his own home. Headaches are very common. Rickettsia causes red blood vessels on the surface of the eye, and unlike bartonella, they cause them to be uniformly red. Some patients have difficulty focusing on the eyes and smudging of the image described as “the feeling of flooded eyes with water”. The most important symptom of infection with this bacterium are musculoskeletal disorders. Patients with these infections suffer from numbness, tingling, pain and burning muscles. Symptoms are vascular and are associated with the musculoskeletal system.

Rickettsia makes the lymphatic system very crowded. An overloaded lymphatic system, trying to clean the lymph from toxins, stops its flow creating swelling. The body can not cope with detoxification and the circulating debris is not adequately filtered by the liver. The liver does not manage to push the muck into the lymphatic system to keep the blood as clean as possible. The blood thickens, the detoxification becomes dysfunctional, and the poisoned body is overcome with general, homogeneous pain.

Rickettsia and its similar bacteria (such as Ehrlichia, Anaplasma and Coxiella burnetii) are an unusual type of bacteria that cause anaplasmosis and ehrlichiosis.

Ehrlichia was recognized as a co-infection of Lyme in 1986. The two known main factors of human ehrlichiosis are E.chaffeensis and E.ewingii. A third species, E.canis, has recently been detected that infects humans, but its importance as a human pathogen is not well understood today.
E.chaffeensis attacks monocytes and is referred to as a “human monocytic ehrlichiosis” factor.

E.ewingii preferentially attacks neutrophils or neutrophils (NEUT), which is similar to anaplasmosis. Common blood tests include leukopenia, thrombocytopenia and elevated serum transaminases.

While some ehrlichiosis cases are mild, the disease can be severe or fatal if not treated properly. Severe symptoms of ehrlichiosis may include difficulty in breathing, respiratory failure, bleeding disorders, renal failure or heart failure. It infects white blood cells (cells that fight infection) and mitochondria (human cell power plant), the consequences of untreated infection can have long-lasting effects. Like other tick-borne diseases, diagnostic blood tests are often false negative during the first weeks of the disease. Like other tick-borne diseases, treatment is most effective if it is started as early as possible.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878868/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193170/
https://europepmc.org/abstract/med/27720381
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182290
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348082/

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